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Department for Immunology and Immunoparasitology

Objectives:

Basic research in the fields of:
A) Immunoparasitology and Autoimmunity
Focus is on the parasite Trichinella spiralis and its products with powerful immunomodulatory capacity. Previous results obtained in experimental models have shown that the products of this parasite could prevent the occurrence or alleviate the course of autoimmune disease. Current research is a translation of knowledge obtained in the animal model to a human in vitro model, towards potential treatment of multiple sclerosis by application of tolerogenic dendritic cells cultivated with T. spiralis products or nanoparticles as carriers of those products. All activities of the research are carried out within the framework of the project:Mechanisms of the immune response to parasitic infection, or exposure to parasite antigens, and the concomitant modulation and/or prevention of unrelated diseases”, Project Leader Dr Ljiljana Sofronić-Milosavljević, Full Research Professor, project no. 173047, Ministry of Education, Science and Technological Development of the Republic of Serbia, (2011- ).
B) Tumor immunlogy focusing on the development of new protocols for the preparation of autologous dendritic cells as tumor vaccines using nanomaterials. Research is carried out within the framework of the project: Application of functionalized carbon nanotubes and gold nanoparticles in the preparation of dendritic cells for tumor therapy, Project Leader Miodrag Čolić, Academician, Full Research Professor, project no. 175102, Ministry of Education, Science and Technological Development of the Republic of Serbia, (2011-).

Applied research 
as connected to basic, enables preparation either components of (antigens, primary or secondary antibodies) or ready for use immunodiagnostic kits (Radial Immunodiffusion Plate-RID, Indirect Fluorescence Antibody Assay-IFA, ELISA) applicable for determination of main classes of immunoglobulins, autoantibody or specific anti-bacterial or anti-parasite antibody presence in animal or human body fluids.

Public health services in the field of competence. Since recently, biocompatibility testing services for materials intended for medical devices has been introduced.

International cooperation:

Within the department there is a National Reference Laboratory for TrichinellosisNRLT INEP, appointed by Serbian Ministry of Health at 2008). NRLT developed cooperation at national level with the Institute of Public Health of Serbia “Dr Milan Jovanović Batut”, Klinical Center of Serbia and hospitals thorough over the country. A significant international reputation was achieved through cooperation with the European Union Reference Laboratory for Parasites, Istituto Superiore di Sanita, Italy (EURLP, ISS, Rome, It, https://w3.iss.it/site/EURLPMaps/MapsInfo.asp). Scientists of this department also have the approval of the Ministry of Agriculture, Forestry and Water Management to represent the Republic of Serbia and veterinary services at the European level (at meetings organized by EURLP, ISS, Rome, It) through the presentation of annual data regarding distribution and prevalence of Trichinella spp. in domestic and wild animals in Serbia.

Continuous and advanced training: INEP, as a member of the University of Belgrade, (including this Department) participates in the laboratory training of students of the Faculty of Chemistry as well as students from abroad (within the exchange of students organized by the MNTR). The department is also recognized as a research basis for graduate and postgraduate thesis preparation for students of the Faculty of Biology.

Department staff:

1. dr Ljiljana Sofronić-Milosavljević, MD, PhD, Professor of Research, Head of Department, sofronic@inep.co.rs
2. Academician, Prof. Dr. Miodrag Čolić, MD, PhD, Professor of Research, mjcolic@inep.co.rs
3. dr Nataša Ilić, Doctor of Biological Sciences, Senior Research Associate, natasa@inep.co.rs
4. dr Saša Vasilev, DVM, PhD, Research Associate, vasilev@inep.co.rs
5. dr Jelena Cvetković, Doctor of Biological Sciences, Research Associate, jelanac@inep.co.rs
6. dr Sergej Tomić, Doctor of Biological Sciences, Research Associate, sergej.tomic@inep.co.rs
7. dr Ivana Mitić, MD, PhD, Research Associate, ivanar@inep.co.rs
8. dr Marija Gnjatović, Engineer of Technology, PhD in Technological Engineering-Biotechnology, Research Associate, marijad@inep.co.rs
9. dr Maja Kosanović, Doctor of Biological Sciences, Research Associate, maja@inep.co.rs
10. Marina Bekić, Master of Biological Sciences, Research Trainee, marina.bekic@inep.co.rs
11. Sofija Glamočlija, Master of Biological Sciences, Research Trainee, sofija.glamoclija@inep.co.rs
12. Aleksandra Todorović, Master Engineer of Technology, Research Trainee, aleksandra.todorovic@inep.co.rs
13. Ljiljana Sabljić, DVM, Research Trainee, ljsabljic@hotmail.com
14. Blagoje Milosavljević, technician in chemistry and technology, technical associate
15. Jelena Milosavljević, technician in chemistry and technology, technical associate